MRTX849 analog 24

MRTX849 analog 24 is an alkyne-containing click probe analogue of KRAS G12C inhibitor MRTX849, which is used to research MRTX849 function[1].

Product Specifications

CAS Number

[2490716-96-4]

UNSPSC

12352005

Target

Fluorescent Dye

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mrtx849-analog-24.html

Purity

98.01

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(CCCC#C)CCC6)=N2)C1

Molecular Formula

C36H39ClFN7O2

Molecular Weight

656.19

References & Citations

[1]Jay B Fell, et al. Identification of the Clinical Development Candidate MRTX849, a Covalent KRAS G12C Inhibitor for the Treatment of Cancer. J Med Chem. 2020 Jul 9;63 (13) :6679-6693.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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