Foliglurax (monohydrochloride)

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM), with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].

Product Specifications

CAS Number

[2133294-96-7]

Product Name Alternative

PXT002331 (monohydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Foliglurax_monohydrochloride.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O/N=C1C=C(C2=CC3=C(C=CS3)C=N2)OC4=CC=C(CCCN5CCOCC5)C=C\14.Cl

Molecular Formula

C23H24ClN3O3S

Molecular Weight

457.97

Precautions

H315, H319, H335

References & Citations

[1]Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60 (20) :8515-8537.|[2]Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13 (5) :411-423.