TDI-011536
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1].
Product Specifications
CAS Number
[2687970-96-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/tdi-011536.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3CO)/N3CC4=CC=CC=C4
Molecular Formula
C19H16N4O2S
Molecular Weight
364.42
Precautions
H302, H315, H319
References & Citations
[1]Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119 (28) :e2206113119.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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