POT-4 (TFA)
Product Specifications
UNSPSC Description
POT-4 TFA (AL-78898A TFA), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 TFA can be used for age-related macular degeneration research[1][2].
Target Antigen
Complement System
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pot-4-tfa.html
Solubility
10 mM in DMSO
Smiles
CN1C2=CC=CC=C2C(C[C@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N3)=O)C(C)C)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O)C(N[C@H](C(N)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)CC4=CN=CN4)=O)C)=O)=O)CC5=CNC6=CC=CC=C56)=O)CC(O)=O)=O)CCC(N)=O)=O)=C1.O=C(O)C(F)(F)F
Molecular Weight
1741.87
References & Citations
[1]S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.|[2]Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3204A/POT-4-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3204A/
Clinical Information
Phase 2
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