Regorafénib N-oxyde (M2)

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Product Specifications

CAS Number

[835621-11-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; PDGFR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Regorafénib_N-oxyde_M2.html

Purity

99.32

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O

Molecular Formula

C21H15ClF4N4O4

Molecular Weight

498.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.