CDPCP
CDPCP (cis-[Pt (NH3) 2 (N1-pyridine) Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters[1][2].
Product Specifications
CAS Number
106343-54-8
Product Name Alternative
Cis-[Pt (NH3) 2 (N1-pyridine) Cl]Cl
UNSPSC
12352005
Hazard Statement
H302, H315, H317, H319, H334, H335
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdpcp.html
Purity
99.9
Smiles
[Cl-][Pt+2]([NH3])([NH3])[N]1=CC=CC=C1.[Cl-]
Molecular Formula
C5H11Cl2N3Pt
Molecular Weight
379.15
Precautions
H302, H315, H317, H319, H334, H335
References & Citations
[1]Lovejoy KS, et al. Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans. 2009 Dec 28; (48) :10651-9. |[2]Lovejoy KS, et al. cis-Diammine (pyridine) chloroplatinum (II), a monofunctional platinum (II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 2008 Jul 1;105 (26) :8902-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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