CDPCP

CDPCP (cis-[Pt (NH3) 2 (N1-pyridine) Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters[1][2].

Product Specifications

CAS Number

[106343-54-8]

Product Name Alternative

Cis-[Pt (NH3) 2 (N1-pyridine) Cl]Cl

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H319, H334, H335

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdpcp.html

Purity

99.9

Smiles

[Cl-][Pt+2]([NH3])([NH3])[N]1=CC=CC=C1.[Cl-]

Molecular Formula

C5H11Cl2N3Pt

Molecular Weight

379.15

Precautions

H302, H315, H317, H319, H334, H335

References & Citations

[1]Lovejoy KS, et al. Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans. 2009 Dec 28; (48) :10651-9. |[2]Lovejoy KS, et al. cis-Diammine (pyridine) chloroplatinum (II), a monofunctional platinum (II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 2008 Jul 1;105 (26) :8902-7.