11-Deoxyglycyrrhetinic acid (sodium)
11-Deoxyglycyrrhetinic acid sodium is a compound that exhibits anti-inflammatory activity. 11-Deoxyglycyrrhetinic acid sodium activates the Ca2+/voltage-gated K+ large conductance (BK) (cbv1 + β1) channels cloned from rat cerebral artery myocytes with the EC50 of 53 μM[1][2].
Product Specifications
CAS Number
1148013-87-9
UNSPSC
12352211
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/11-deoxyglycyrrhetinic-acid-sodium.html
Smiles
C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O[Na])=O)C)C)([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC1)C
Molecular Formula
C30H47NaO3
Molecular Weight
478.68
References & Citations
[1]Siviy SM, et al. Noradrenergic modulation of play in Sprague-Dawley and F344 rats. Psychopharmacology (Berl) . 2023 Jul 10. |[2]Bukiya AN, et al. Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent. Mol Pharmacol. 2013;83 (5) :1030-1044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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