Azemiopsin
Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR[1].
Product Specifications
CAS Number
1391936-86-9
UNSPSC
12352209
Target
NAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azemiopsin.html
Purity
99.31
Solubility
H2O : 16.67 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CNC=N8)C(N[C@@H](CCC(N)=O)C(NCC(N9[C@@H](CCC9)C(N[C@@H](CCCNC(N)=N)C(N%10[C@@H](CCC%10)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCNC(N)=N)C(N%12[C@@H](CCC%12)C(N[C@@H](CCCNC(N)=N)C(N%13[C@@H](CCC%13)C(N[C@@H](CCCCN)C(N%14[C@@H](CCC%14)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Molecular Formula
C118H174N38O26
Molecular Weight
2540.88
References & Citations
[1]Utkin YN, et al. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem. 2012 Aug 3;287 (32) :27079-86.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E-UNEL-M0175-01 5x 96 Tests
Uncoated Mouse NOV (Nephroblastoma Overexpressed Gene) ELISA Kit
Sign In for Pricing
View Details E-UNEL-M0175-02 15x 96 Tests
Uncoated Mouse NOV (Nephroblastoma Overexpressed Gene) ELISA Kit
Sign In for Pricing
View Details 
