Azemiopsin

Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR[1].

Product Specifications

CAS Number

[1391936-86-9]

UNSPSC

12352209

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/azemiopsin.html

Purity

99.31

Solubility

H2O : 16.67 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CCCCN)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CNC=N8)C(N[C@@H](CCC(N)=O)C(NCC(N9[C@@H](CCC9)C(N[C@@H](CCCNC(N)=N)C(N%10[C@@H](CCC%10)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCNC(N)=N)C(N%12[C@@H](CCC%12)C(N[C@@H](CCCNC(N)=N)C(N%13[C@@H](CCC%13)C(N[C@@H](CCCCN)C(N%14[C@@H](CCC%14)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

Molecular Formula

C118H174N38O26

Molecular Weight

2540.88

References & Citations

[1]Utkin YN, et al. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem. 2012 Aug 3;287 (32) :27079-86.