Dentonin (TFA)

Dentonin TFA (AC-100 TFA) is a synthetic fragment derived from MEPE. Dentonin TFA enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin TFA has no significant effect to mature osteoblasts. Dentonin TFA can be used for the research of phosphate homeostasis and bone metabolism[1].

Product Specifications

Product Name Alternative

AC-100 (TFA)

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dentonin-tfa.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CCC2)=O)CCC(N)=O)=O)=O)CC(O)=O)=O)=O)CO)=O)CC4=CC=CC=C4)=O)CCC1)=O)CO)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(O)=O.OC(C(F)(F)F)=O

Molecular Formula

C109H161F3N30O44

Molecular Weight

2652.61

References & Citations

[1]Andrew P Sprowson, et al. ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion. J Orthop Res. 2008 Sep;26 (9) :1256-62.|[2]N Six, et al. Dentonin, a MEPE fragment, initiates pulp-healing response to injury.J Dent Res. 2007 Aug;86 (8) :780-5.