Androgen receptor-IN-3

Androgen receptor-IN-3 (Compound 22) is an androgen receptor inhibitor. Androgen receptor-IN-3 inhibits AR-driven transcriptional activity in LNCaP cells, with an IC50 of 5.04 μM[1].

Product Specifications

CAS Number

[926228-58-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/androgen-receptor-in-3.html

Solubility

10 mM in DMSO

Smiles

OCC1=C(C2=CC=CC=C2)N=C(N3CCOCC3)S1

Molecular Formula

C14H16N2O2S

Molecular Weight

276.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Li H, et al. Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor. J Med Chem. 2014 Aug 14;57 (15) :6458-67.