(S, S) -TAPI-1

(S, S) -TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor[1][2].

Product Specifications

CAS Number

[171235-71-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR; MMP

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-s-tapi-1.html

Purity

99.46

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=C2C=CC=CC2=C1)C(N[C@@H](C)C(NCCN)=O)=O)C(CC(C)C)CC(NO)=O

Molecular Formula

C26H37N5O5

Molecular Weight

499.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22 (2) :135-143.|[2]Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.|[3]Slack B E, et al., Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme[J]. Biochemical Journal, 2001, 357 (3) : 787-794.