(-) -CMLD010509
(-) -CMLD010509 ((-) -SDS-1-021) is an isomer of CMLD010509 (SDS-1-021) (HY-119271) . CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM) -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism[1].
Product Specifications
CAS Number
[2240186-24-5]
Product Name Alternative
(-) -SDS-1-021
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/minus-cmld010509.html
Smiles
O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)Br)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(NOC)=O
Molecular Formula
C27H26BrNO7
Molecular Weight
556.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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