(-) -CMLD010509

(-) -CMLD010509 ((-) -SDS-1-021) is an isomer of CMLD010509 (SDS-1-021) (HY-119271) . CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM) -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism[1].

Product Specifications

CAS Number

[2240186-24-5]

Product Name Alternative

(-) -SDS-1-021

UNSPSC

12352005

Target

Apoptosis; c-Myc

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/minus-cmld010509.html

Smiles

O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)Br)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(NOC)=O

Molecular Formula

C27H26BrNO7

Molecular Weight

556.40

References & Citations

[1]Manier S, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9 (389) . pii: eaal2668.