O-GlcNAcase-IN-2
O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM) . O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects[1].
Product Specifications
UNSPSC
12352005
Target
OGA
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/o-glcnacase-in-2.html
Smiles
CC(NC(S1)=NC=C1CN(CC2)CCC2C#CC3=CC(CCCN4)=C4C=C3)=O
Molecular Formula
C22H26N4OS
Molecular Weight
394.53
References & Citations
[1]Discovery of 4- (Arylethynyl) piperidine Derivatives as Potent Nonsaccharide O-GlcNAcase Inhibitors for the Treatment of Alzheimer’s Disease
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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