Cucurbitacin I
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.
Product Specifications
CAS Number
[2222-07-3]
Product Name Alternative
Elatericin B; JSI-124; NSC-521777
UNSPSC
12352211
Hazard Statement
H300
Target
JAK; STAT
Type
Natural Products
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Cucurbitacin-I.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)(C1=CC[C@@]2([H])[C@@]3(C[C@@H](O)[C@@H]([C@]3(C4)C)[C@@](C)(O)C(/C=C/C(C)(O)C)=O)C)C(C(O)=C[C@@]1([H])[C@]2(C)C4=O)=O
Molecular Formula
C30H42O7
Molecular Weight
514.65
Precautions
H300
References & Citations
[1]Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33 (4) :1867-71.|[2]Moon Hee Jeong, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10 (8) :e0136236.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JAK2; STAT3
Available Sizes
Curated Selection
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