Nafithromycin
Nafithromycin (WCK 4873) is an orally available antibiotic that inhibits community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Methicillin -susceptible Staphylococcus aureus. The MIC90 of nafithromycin against macrolide-resistant and telithromycin (HY-A0062) -insensitive Streptococcus pneumoniae is 0.12 mg/liter[1].
Product Specifications
CAS Number
1691240-78-4
Product Name Alternative
WCK 4873
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nafithromycin.html
Smiles
C[C@@]12[C@]([C@H](C([C@@H](C[C@](C)([C@@H]([C@H](C([C@H](C(O[C@@H]2CC)=O)C)=O)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)OC)C)=O)C)([H])[C@@H](C(O1)=O)/C(N)=N/O[C@H](C4=NN=C(C5=CC=CC=N5)S4)C
Molecular Formula
C42H62N6O11S
Molecular Weight
859.04
References & Citations
[1]Kohlhoff, et al. "In vitro activity of nafithromycin (WCK 4873) against Chlamydia pneumoniae." Antimicrobial Agents and Chemotherapy 65.9 (2021) : 10-1128.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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