VU0092273

VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM[1][2].

Product Specifications

CAS Number

[393110-43-5]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0092273.html

Smiles

O=C(N1CCC(O)CC1)C2=CC=C(C#CC3=CC=CC=C3)C=C2

Molecular Formula

C20H19NO2

Molecular Weight

305.37

References & Citations

[1]Douglas J Sheffler, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22 (12) :3921-5.|[2]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78 (6) :1105-23.