Sp1 (Acetyl Lys703) rabbit pAb

Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter. PTM: O-glycosylated; contains N-acetylglucosamine side chains. similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. similarity: Contains 3 C2H2-type zinc fingers. subunit: Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.

Product Specifications

Background

Function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter., PTM:O-glycosylated; contains N-acetylglucosamine side chains., similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family., similarity:Contains 3 C2H2-type zinc fingers., subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.

UniProt

P08047

Swiss Prot

P08047

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human Sp1 (Acetyl Lys703)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

90kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

90kD

Fragment

IgG

Subcellular Location

Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.