SIRT6-IN-2

SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM) . SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].

Product Specifications

CAS Number

[891002-11-2]

UNSPSC

12352005

Hazard Statement

H315

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sirt6-in-2.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(NC(C2=CC=CO2)=O)C=C1)NC3=CC(C(O)=O)=C(O)C=C3

Molecular Formula

C19H14N2O6

Molecular Weight

366.32

Precautions

P264-P280-P302+P352-P362

References & Citations

[1]Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25 (20) :5849-5858.