Recombinant UBE2R1 Protein

<strong>Recombinant UBE2R1 Protein</strong>_x000D_ <strong>Catalog number:</strong> B2017708_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 28.9 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Ubiquitin conjugating enzyme E2 R1, E2-CDC34, UBC3, UBCH3, CDC34, Cell division cycle 34 homolog_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Katayama K, Noguchi K, Sugimoto Y. FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells Cancer Sci. 2013 Jun;104(6):694-702._x000D_ 2: Hill S, Hill C, Kleiger G. Using In Vitro Ubiquitylation Assays to Estimate the Affinities of Ubiquitin-Conjugating Enzymes for Their Ubiquitin Ligase Partners Methods Mol Biol. 2018;1844:39-58._x000D_ 3: Xu M, Zhang J. A siRNA screening of UBE2 family demonstrated that UBE2R1 had a high repressive effect on HIV Tat protein Biochem Biophys Rep. 2022 Oct 15;32:101366._x000D_ 4: Hill S, Harrison JS, Lewis SM, Kuhlman B, Kleiger G. Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme Mol Cell Biol. 2016 May 16;36(11):1720-32._x000D_ 5: Katayama K, Fujiwara C, Noguchi K, Sugimoto Y. RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1 Sci Rep. 2016 Oct 27;6:36134._x000D_ 6: Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases Mol Cell Proteomics. 2021;20:100019._x000D_ 7: Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, Kleiger G. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways Elife. 2019 Dec 23;8:e51163._x000D_ 8: Choi YS, Lee YJ, Lee SY, Shi L, Ha JH, Cheong HK, Cheong C, Cohen RE, Ryu KS. Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities J Biol Chem. 2015 Jan 23;290(4):2251-63._x000D_ 9: Le TT, Ainsworth J, Polo Rivera C, Macartney T, Labib KPM. Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes Biochem J. 2021 Jul 30;478(14):2825-2842._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/25527291">10: Wauer T, Swatek KN, Wagstaff JL, Gladkova C, Pruneda JN, Michel MA, Gersch M, Johnson CM, Freund SM, Komander D. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis EMBO J. 2015 Feb 3;34(3):307-25. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant UBE2R1 Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>