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L 684248

L-684248 is an inhibitor of human leukocyte elastase (HLE) . L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research[1].

Product Specifications

CAS Number

[156728-18-6]

UNSPSC

12352005

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l-684248.html

Smiles

O=C(O)C1=CC=C(O[C@@H](C2(C)C)N(C(N[C@@H](C3=CC=C(C)C=C3)CCC)=O)C2=O)C=C1

Molecular Formula

C24H28N2O5

Molecular Weight

424.49

References & Citations

[1]Underwood DJ, et al. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes. Biochemistry. 1995 Nov 7;34 (44) :14344-55.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-117591/L-684248-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-117591/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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