L 684248
L-684248 is an inhibitor of human leukocyte elastase (HLE) . L-684248 exerts its inhibitory effect on HLE by forming a covalent bond with the active site of the enzyme, showing potential value for applications in anti-inflammatory and anti-tumor research[1].
Product Specifications
CAS Number
156728-18-6
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-684248.html
Smiles
O=C(O)C1=CC=C(O[C@@H](C2(C)C)N(C(N[C@@H](C3=CC=C(C)C=C3)CCC)=O)C2=O)C=C1
Molecular Formula
C24H28N2O5
Molecular Weight
424.49
References & Citations
[1]Underwood DJ, et al. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes. Biochemistry. 1995 Nov 7;34 (44) :14344-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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