EGFR-IN-104
EGFR-IN-104 (Compound A23) is an effective inhibitor of EGFR, with IC50 values of 0.33 μM and 0.133 μM against EGFRL858R/T790M and EGFRDel19/T790M/C797S, respectively. EGFR-IN-104 exhibits anticancer activity both in vitro and in vivo[1].
Product Specifications
CAS Number
2758904-45-7
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-104.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=CC=C1C2=NC(CCSC3)=C3C(NCC4=CN=C(N5CCN(C)CC5)N=C4)=N2
Molecular Formula
C23H27N7OS
Molecular Weight
449.57
References & Citations
[1]Xu S, et al. Novel bioactive 2-phenyl-4-aminopyrimidine derivatives as EGFRDel19/T790M/C797S inhibitors for the treatment of non-small cell lung cancer. Arch Pharm (Weinheim) . 2024 Feb;357 (2) :e2300460.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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