M65 TFA

M65 TFA is a deleted peptide of maxadilan (61 a.a.) with deletion of the residues between positions 24 and 42 and is a specific antagonist of PACAP type 1 receptor that inhibits ANP secretion and can be used for relevant researches[1][2].

Product Specifications

UNSPSC

12352209

Target

PACAP Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/m65-tfa.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CCC(O)=O)=O)CCCCN)=O)CC4=CC=CC=C4)=O)C(C)C)=O)CO)=O)CC(N)=O)=O)=O)CCC2)=O)C(C)C)=O)CC(N)=O)=O)CO)=O)CC5=CNC=N5)=O)CC6=CNC=N6)=O)C)=O)CCC(N)=O)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCCCN)=O)CC7=CC=CC=C7)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN)=O)CCC(N)=O)=O)CCCCN)=O)CCSC)=O)=O)CC(O)=O)=O)CC(O)=O)=O)[C@H](CC)C)=O)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CC8=CC=CC=C8)=O)CCC(N)=O)=O)N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)C)=O)CC(O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C205H326N64O61S5.xC2HF3O2

Molecular Weight

4823.53 (free base)

References & Citations

[1]Lerner EA, et al. Maxadilan, a PAC1 receptor agonist from sand flies. Peptides. 2007 Sep;28 (9) :1651-4.|[2]Uchida D, et al. Maxadilan is a specific agonist and its deleted peptide (M65) is a specific antagonist for PACAP type 1 receptor. Ann N Y Acad Sci. 1998 Dec 11;865:253-8.