IRF1-IN-1

IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1) . IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].

Product Specifications

CAS Number

[701225-07-2]

UNSPSC

12352005

Target

Caspase; IFNAR; Interleukin Related; PARP; Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/irf1-in-1.html

Purity

99.72

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=CN1CCC(NC3=CC=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=CC=C2

Molecular Formula

C22H24N4O4S

Molecular Weight

440.52

References & Citations

[1]Geng, et al. Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response. Cell Mol Immunol. 2024 Aug;21 (8) :856-872.