IRF1-IN-1
IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1) . IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].
Product Specifications
CAS Number
701225-07-2
UNSPSC
12352005
Target
Caspase; IFNAR; Interleukin Related; PARP; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irf1-in-1.html
Purity
99.72
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=CN1CCC(NC3=CC=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=CC=C2
Molecular Formula
C22H24N4O4S
Molecular Weight
440.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1; PARP1
Available Sizes
Frequently Asked Questions
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