BRL 22321 (free base)

BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium (HY-B0320A) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium (HY-B0320A) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells[1].

Product Specifications

CAS Number

[72364-91-1]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/brl-22321-free-base.html

Smiles

O=C(C1=C(C2=O)C=C(C(C)=C1)C)C3=C2NN=N3

Molecular Formula

C12H9N3O2

Molecular Weight

227.22

References & Citations

[1]Spicer, et al. "BRL 22321, a compound that has mast cell stabilizing activity similar to that of disodium cromoglycate and in addition has smooth muscle relaxing activity." Agents and Actions 13 (1983) : 301-309.