BVB808

BVB808 (NVP_BVB808) is a selective JAK2 inhibitor with approximately 10-fold selectivity for JAK2 over other JAK family members (such as JAK1, JAK3 or TYK2) in vitro. BVB808 inhibits the activity of JAK2 and reduces the phosphorylation of STAT5, thereby blocking the JAK2-dependent cell proliferation and survival signaling pathways. BVB808 can be used in cancer research[1].

Product Specifications

CAS Number

1414587-22-6

Product Name Alternative

NVP_BVB808

UNSPSC

12352005

Target

JAK; STAT

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bvb808.html

Smiles

FC(C=C1N2C3=NC(NC4=CC=C(N5C[C@@H](N[C@@H](C5)C)C)C=C4)=NC=C3C=C2)=C(C(F)=C1)CN6CCOCC6

Molecular Formula

C29H33F2N7O

Molecular Weight

533.62

References & Citations

[1]Weigert, et al. "Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition." The Journal of experimental medicine 209.2 (2012) : 259.