S-14506

S-14506 hydrochloride is a potent 5-HT1A agonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2].

Product Specifications

CAS Number

[135722-25-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-14506.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)F)NCCN2CCN(CC2)C3=C4C=C(C=CC4=CC=C3)OC

Molecular Formula

C24H26FN3O2

Molecular Weight

407.48

Precautions

P261-P280-P302+P352

References & Citations

[1]Francis C. Colpaert, et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. 1992, 21-48.|[2]Protais P, et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur J Pharmacol. 1994 Dec 12;271 (1) :167-77.