Magic™ Membrane Protein Human CXCL12 (C-X-C motif chemokine ligand 12)

SDF-1α is a chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1 α activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1α acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. SDF-1α stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase.