OPC 4392 (hydrochloride)

OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480) -induced dopamine accumulation, inhibits Apomorphine (HY-12723) -induced stereotypic and climbing behaviors in mouse models[1].

Product Specifications

CAS Number

[1329509-60-5]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/opc-4392-hydrochloride.html

Purity

98.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=C(N1)C=C(OCCCN3CCN(CC3)C4=CC=CC(C)=C4C)C=C2.Cl

Molecular Formula

C24H30ClN3O2

Molecular Weight

427.97

References & Citations

[1]Yasuda Y, et al., 7-[3- (4-[2,3-Dimethylphenyl]piperazinyl) propoxy]-2 (1H) -quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42 (20) :1941-54.