Dihydrobaicalein
Dihydrobaicalein is a PLK1 Inhibitor with an IC50 of 6.3 μM. Dihydrobaicalein also inhibits VRK2 and PLK2. Dihydrobaicalein is a natural product that can be isolated from Scutellaria scandens[1].
Product Specifications
CAS Number
[35683-17-1]
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dihydrobaicalein.html
Purity
99.94
Solubility
DMSO : 2.72 mg/mL (ultrasonic; warming)
Smiles
O=C1CC(C2=CC=CC=C2)OC3=CC(O)=C(O)C(O)=C13
Molecular Formula
C15H12O5
Molecular Weight
272.25
References & Citations
[1]Woo SU, et al. 7-O-Methylwogonin from Scutellaria baicalensis Disturbs Mitotic Progression by Inhibiting Plk1 Activity in Hep3B Cells. Planta Med. 2019 Feb;85 (3) :217-224.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PLK1
Available Sizes
Curated Selection
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