BMS-192364

BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].

Product Specifications

CAS Number

[202822-21-7]

Product Name Alternative

1,25-Dihydroxyvitamin D3

UNSPSC

12352005

Target

Calcium Channel; RGS Protein

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-192364.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC(Cl)=CC=C2O)NC(C3=CC=C(C(F)(F)F)C=C3)=N1

Molecular Formula

C15H9ClF3N3O2

Molecular Weight

355.70

References & Citations

[1]Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2 (4) :e57.|[2]Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38 (4) :344-54.|[3]David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80 (3) :233-5.