TP-040
TP-040 (O-GlcNAcase-IN-1), a chemical probe, is a potent and novel OGA inhibitor with an IC50 value of 46 nM.
Product Specifications
CAS Number
[2757254-99-0]
Product Name Alternative
O-GlcNAcase-IN-1
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
OGA
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-040.html
Purity
98.59
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1CCN(C2=NC(NCC3=CN(C)C=N3)=NC=C2)CC1
Molecular Formula
C15H22N6
Molecular Weight
286.38
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64 (2) :1103-1115.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6222186-01 0.1 mL
FHIT (Fragile Histidine Triad Protein, AP3A Hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5',5'''-P1,P3-triphosphate Hydrolase, Dinucleosidetriphosphatase, FRA3B) (MaxLight 650)
Ask
View Details MBS6222186-02 5x 0.1 mL
FHIT (Fragile Histidine Triad Protein, AP3A Hydrolase, AP3Aase, Bis(5'-adenosyl)-triphosphatase, Diadenosine 5',5'''-P1,P3-triphosphate Hydrolase, Dinucleosidetriphosphatase, FRA3B) (MaxLight 650)
Ask
View Details 
MBS8423171-01 0.12 mL
Rabbit Anti CDADC1 Polyclonal Antigen affinity Purified (PBS with 0.05% NaN3 and 40% Glycerol, pH7.4)(Western Blot, IHC, ELISA)
Ask
View Details 
MBS8423171-02 0.2 mL
Rabbit Anti CDADC1 Polyclonal Antigen affinity Purified (PBS with 0.05% NaN3 and 40% Glycerol, pH7.4)(Western Blot, IHC, ELISA)
Ask
View Details MBS8423171-03 5x 0.2 mL
Rabbit Anti CDADC1 Polyclonal Antigen affinity Purified (PBS with 0.05% NaN3 and 40% Glycerol, pH7.4)(Western Blot, IHC, ELISA)
Ask
View Details