TP-040
Product Specifications
Product Name Alternative
O-GlcNAcase-IN-1
UNSPSC Description
TP-040 (O-GlcNAcase-IN-1) is a potent and novel OGA inhibitor with an IC50 value of 46 nM.
Target Antigen
OGA
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-040.html
Purity
98.59
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC1CCN(C2=NC(NCC3=CN(C)C=N3)=NC=C2)CC1
Molecular Weight
286.38
References & Citations
[1]Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64(2):1103-1115.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131979/TP-040-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131979/TP-040-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2757254-99-0
Available Sizes
Curated Selection
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