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Azurin p28 peptide (TFA)

Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; MDM-2/p53

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azurin-p28-peptide-tfa.html

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H](CCSC)NC(CNC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CC(O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C122H197N31O47S2.xCF3COOH

Molecular Weight

2914.18 (free base)

References & Citations

[1]Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14 (3) :355-69.|[2]Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68 (2) :513-24.|[3]Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8 (10) :2947-58.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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