Aminoadipic acid

Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].

Product Specifications

CAS Number

[542-32-5]

Product Name Alternative

YH439

UNSPSC

12352211

Hazard Statement

H317

Target

Calcium Channel; Endogenous Metabolite; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; SOD

Type

Natural Products

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Aminoadipic_acid.html

Purity

99.86

Solubility

DMSO : 2 mg/mL (ultrasonic) |H2O : 2.86 mg/mL (ultrasonic)

Smiles

O=C(O)C(N)CCCC(O)=O

Molecular Formula

C6H11NO4

Molecular Weight

161.16

Precautions

H317

References & Citations

[1]Wang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123 (10) :4309-17.|[2]Wang X, et al. α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. Drug Des Devel Ther. 2016 Oct 20;10:3449-3457.|[3]Estaras M, et al. The lysine derivative aminoadipic acid, a biomarker of protein oxidation and diabetes-risk, induces production of reactive oxygen species and impairs trypsin secretion in mouse pancreatic acinar cells. Food Chem Toxicol. 2020 Nov;145:111594.|[4]Wang T, et al. Aminoadipic acid aggravates atherosclerotic vascular inflammation through ROS/TXNIP/NLRP3 pathway, a harmful microbial metabolite reduced by paeonol. Int J Biochem Cell Biol. 2024 Dec;177:106678.