DGY-06-116

DGY-06-116 is an irreversible covalent, selective Src inhibitor with an IC50 of 3nM. DGY-06-116 inhibits FGFR1 with an IC50 of 8340 nM[1].

Product Specifications

CAS Number

[2556836-50-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dgy-06-116.html

Purity

99.54

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(Cl)C=CC=C1C)C(C=N2)=C(NC3=C(NC(C=C)=O)C=CC=C3)N=C2NC4=CC=C(N5CCN(C)CC5)C=C4

Molecular Formula

C32H33ClN8O2

Molecular Weight

597.11

Precautions

P264-P270-P330-P501

References & Citations

[1]Guangyan Du, et al. Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine. J Med Chem. 2020 Feb 27;63 (4) :1624-1641.|[2]Deepak Gurbani, et al. Structure and Characterization of a Covalent Inhibitor of Src Kinase. Front Mol Biosci. 2020 May 19;7:81.