TM-25659

TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities[1].

Product Specifications

CAS Number

[260553-97-7]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/TM-25659.html

Purity

99.33

Solubility

DMSO : ≥ 135 mg/mL

Smiles

CC1=C(C2=CC=CN=C2)C=C3C(N(CC4=CC=C(C5=CC=CC=C5C6=NN=NN6)C=C4)C(CCCC)=N3)=N1

Molecular Formula

C30H28N8

Molecular Weight

500.60

Precautions

H228, H315, H319

References & Citations

[1]Jang EJ, et al. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br J Pharmacol. 2012 Mar;165 (5) :1584-94.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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