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Topoisomerase II inhibitor 14

Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibtor. Topoisomerase II inhibitor 14 induces apoptosis and arrests cell cycle at S phase and G2-M phases. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO. Topoisomerase II inhibitor 14 can be used for the study of neck squamous cell carcinoma (HNSCC) [1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-14.html

Purity

99.68

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC(C2=CC=C(Cl)C=C2Cl)N3C4=CC=CC=C4N=C3N1

Molecular Formula

C15H11Cl2N5

Molecular Weight

332.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W278582/Topoisomerase-II-inhibitor-14-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W278582/Topoisomerase-II-inhibitor-14-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[305343-00-4]

Available Sizes

Curated Selection

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