Zorevunersen (sodium)
Zorevunersen sodium is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen sodium is used for the study of Dravet syndrome.
Product Specifications
CAS Number
2415330-05-9
Product Name Alternative
STK-001 (sodium)
UNSPSC
12352208
Target
Sodium Channel
Type
Oligonucleotides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/zorevunersen-sodium.html
Purity
98.25
Solubility
H2O : ≥ 20 mg/mL
Smiles
[Zorevunersen(sodium)]
Molecular Formula
C234H317N71Na17O124P17S17
Molecular Weight
7197.2 (free acid)
References & Citations
[1]Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743. |[2]Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI) : II. Drugs in more advanced clinical development. Epilepsia. 2022;63 (11) :2883-2910.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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