Zorevunersen (sodium)

Zorevunersen sodium is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen sodium is used for the study of Dravet syndrome.

Product Specifications

CAS Number

[2415330-05-9]

Product Name Alternative

STK-001 (sodium)

UNSPSC

12352208

Target

Sodium Channel

Type

Oligonucleotides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zorevunersen-sodium.html

Purity

98.25

Solubility

H2O : ≥ 20 mg/mL

Smiles

[Zorevunersen(sodium)]

Molecular Formula

C234H317N71Na17O124P17S17

Molecular Weight

7197.2 (free acid)

References & Citations

[1]Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743. |[2]Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI) : II. Drugs in more advanced clinical development. Epilepsia. 2022;63 (11) :2883-2910.