Bosutinib isomer
Product Specifications
UNSPSC Description
Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively[1].
Target Antigen
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bosutinib-isomer.html
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N#CC1=C(NC2=CC(Cl)=C(OC)C(Cl)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1
Molecular Weight
530.45
References & Citations
[1]Zhu JY, et al. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem. 2017 Sep 28;60(18):7863-7875.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103029/Bosutinib-isomer-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103029/Bosutinib-isomer-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1391063-17-4
Available Sizes
Curated Selection
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