Bosutinib isomer

Bosutinib isomer is a ligand or inhibitor with high binding affinity for both Wee1 and Wee2, with Kd values of 43.7 ± 10.0 and 4.7 ± 2.3 nM, respectively[1].

Product Specifications

CAS Number

[1391063-17-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bosutinib-isomer.html

Purity

99.62

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=C(NC2=CC(Cl)=C(OC)C(Cl)=C2)C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=C1

Molecular Formula

C26H29Cl2N5O3

Molecular Weight

530.45

Precautions

H315, H319, H320

References & Citations

[1]Zhu JY, et al. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem. 2017 Sep 28;60 (18) :7863-7875.