2,3,4,6,7,8-Hexachlorodibenzofuran

2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF) . 2,3,4,6,7,8-Hexachlorodibenzofuran induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 0.687 and 0.575 nM, respectively) [1][2].

Product Specifications

CAS Number

[60851-34-5]

Product Name Alternative

2,3,4,6,7,8-HxCDF

UNSPSC

12352005

Hazard Statement

H301-H319-H413

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/2-3-4-6-7-8-hexachlorodibenzofuran.html

Smiles

ClC1=C(Cl)C(Cl)=C(OC2=C(Cl)C(Cl)=C(Cl)C=C23)C3=C1

Molecular Formula

C12H2Cl6O

Molecular Weight

374.86

Precautions

P264-P270-P273-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Harnly M, et al. Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contamination at Metal Recovery Facilities, Open Burn Sites, and a Railroad Car Incineration Facility. Environ Sci Technol. 1995 Mar 1;29 (3) :677-84. |[2]Bandiera S, et al. Polychlorinated dibenzofurans (PCDFs) : effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32 (2) :131-44.