Tezosentan
Product Specifications
UNSPSC Description
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
Target Antigen
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Tezosentan.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=NC=C(C(C)C)C=C1)(NC2=NC(C3=CC(C4=NNN=N4)=NC=C3)=NC(OCCO)=C2OC5=CC=CC=C5OC)=O
Molecular Weight
605.63
References & Citations
[1]Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290(2):840-6.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-17351/Tezosentan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-17351/Tezosentan-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
180384-57-0
Available Sizes
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