Tezosentan
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
Product Specifications
CAS Number
180384-57-0
Product Name Alternative
RO 610612
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Tezosentan.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=NC=C(C(C)C)C=C1)(NC2=NC(C3=CC(C4=NNN=N4)=NC=C3)=NC(OCCO)=C2OC5=CC=CC=C5OC)=O
Molecular Formula
C27H27N9O6S
Molecular Weight
605.63
Precautions
H300+H310+H330
References & Citations
[1]Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290 (2) :840-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
ETA; ETB
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KBH7707 1x 96 Well
GENLISA Human Anti Epidemic Rrhagic Fever (EHF Ab) ELISA
Sign In for Pricing
View Details YLA2567HU-01 48 Tests
Human tyrosine kinase with immunoglobulin-like and EGF-like domains 1, Tie1 ELISA kit
Sign In for Pricing
View Details YLA2567HU-02 96 Tests
Human tyrosine kinase with immunoglobulin-like and EGF-like domains 1, Tie1 ELISA kit
Sign In for Pricing
View Details 
