Tezosentan
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
Product Specifications
CAS Number
[180384-57-0]
Product Name Alternative
RO 610612
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Tezosentan.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=NC=C(C(C)C)C=C1)(NC2=NC(C3=CC(C4=NNN=N4)=NC=C3)=NC(OCCO)=C2OC5=CC=CC=C5OC)=O
Molecular Formula
C27H27N9O6S
Molecular Weight
605.63
Precautions
H300+H310+H330
References & Citations
[1]Clozel M, et al. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther. 1999 Aug;290 (2) :840-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
ETA; ETB
Available Sizes
Curated Selection
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