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[Nphe1]Nociceptin (1-13) NH2

[Nphe1]Nociceptin (1-13) NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin (1-13) NH2 binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0) . [Nphe1]Nociceptin (1-13) NH2 has the potential to act as an analgesic agent[1].

Product Specifications

CAS Number

267234-08-2

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nphe1-nociceptin-1-13-nh2.html

Solubility

10 mM in DMSO

Smiles

[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CCCNC(=N)N)=O)C)=O)CO)=O)CCCCN)=O)CCCNC(=N)N)=O)C)=O)=O)[C@@H](C)O)=O)NC(CNC(CNC(CNCC2=CC=CC=C2)=O)=O)=O

Molecular Formula

C61H100N22O15

Molecular Weight

1381.59

References & Citations

[1]Y Hashimoto, et al. Antagonistic effects of [Nphe1]nociceptin (1-13) NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor|[2]G Calo', et al. Characterization of [Nphe (1) ]nociceptin (1-13) NH (2), a new selective nociceptin receptor antagonist. Br J Pharmacol. 2000 Mar;129 (6) :1183-93.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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