DNA-PK-IN-13
Product Specifications
UNSPSC Description
DNA-PK-IN-13 (Compound SK10) is a DNA-PK inhibitor that exhibits potent inhibitory activity (IC50= 0.11 nM). DNA-PK-IN-13 regulates tumor cell proliferation by decreasing the expression level of γH2A.X and enhancing the sensitivity of tumor cells to chemotherapeutic agents. DNA-PK-IN-13 is suitable for oncology studies[1].
Target Antigen
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dna-pk-in-13.html
Solubility
10 mM in DMSO
Smiles
CC(C(NC1=NC=C2C(N(CC3=NN=CN23)C4CCOCC4)=N1)=C5)=CC6=C5N=CC=C6
Molecular Weight
414.46
References & Citations
[1]Cheng B, Y et al. Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6253-6267
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158166/DNA-PK-IN-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158166/
Clinical Information
No Development Reported
Curated Selection
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