DNA-PK-IN-13

Product Specifications

UNSPSC Description

DNA-PK-IN-13 (Compound SK10) is a DNA-PK inhibitor that exhibits potent inhibitory activity (IC50= 0.11 nM). DNA-PK-IN-13 regulates tumor cell proliferation by decreasing the expression level of γH2A.X and enhancing the sensitivity of tumor cells to chemotherapeutic agents. DNA-PK-IN-13 is suitable for oncology studies[1].

Target Antigen

DNA-PK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dna-pk-in-13.html

Solubility

10 mM in DMSO

Smiles

CC(C(NC1=NC=C2C(N(CC3=NN=CN23)C4CCOCC4)=N1)=C5)=CC6=C5N=CC=C6

Molecular Weight

414.46

References & Citations

[1]Cheng B, Y et al. Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6253-6267